Assessment of cardiac proteome dynamics with heavy water: slower protein synthesis rates in interfibrillar than subsarcolemmal mitochondria

Traditional proteomics provides static assessment of protein content, but not synthetic rates. Recently, proteome dynamics with heavy water ((2)H(2)O) was introduced, where (2)H labels amino acids that are incorporated into proteins, and the synthesis rate of individual proteins is calculated using...

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Hlavní autoři: Kasumov, Takhar, Dabkowski, Erinne R., Shekar, Kadambari Chandra, Li, Ling, Ribeiro, Rogerio F., Walsh, Kenneth, Previs, Stephen F., Sadygov, Rovshan G., Willard, Belinda, Stanley, William C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652088/
https://ncbi.nlm.nih.gov/pubmed/23457012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00933.2012
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