Assessment of cardiac proteome dynamics with heavy water: slower protein synthesis rates in interfibrillar than subsarcolemmal mitochondria

Traditional proteomics provides static assessment of protein content, but not synthetic rates. Recently, proteome dynamics with heavy water ((2)H(2)O) was introduced, where (2)H labels amino acids that are incorporated into proteins, and the synthesis rate of individual proteins is calculated using...

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Bibliografiske detaljer
Main Authors: Kasumov, Takhar, Dabkowski, Erinne R., Shekar, Kadambari Chandra, Li, Ling, Ribeiro, Rogerio F., Walsh, Kenneth, Previs, Stephen F., Sadygov, Rovshan G., Willard, Belinda, Stanley, William C.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2013
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Call for Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652088/
https://ncbi.nlm.nih.gov/pubmed/23457012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00933.2012
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