Dominant negative PPARγ promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle

Agonists of the nuclear hormone receptor peroxisome proliferator-activated receptor γ (PPARγ) have potent insulin-sensitizing effects and inhibit atherosclerosis progression in patients with Type II diabetes. Conversely, missense mutations in the ligand-binding domain of PPARγ that render the transc...

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Autores principales: Pelham, Christopher J., Keen, Henry L., Lentz, Steven R., Sigmund, Curt D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652079/
https://ncbi.nlm.nih.gov/pubmed/23447133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00607.2012
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