Endothelium-Specific Interference with PPARγ Causes Cerebral Vascular Dysfunction in Response to a High Fat Diet

The ligand-activated transcription factor PPARγ is expressed in vascular endothelium where it exerts anti-inflammatory and anti-oxidant effects. However, its role in regulating vascular function remains undefined. We examined endothelial function in transgenic mice expressing dominant negative mutan...

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Main Authors: Beyer, Andreas M., de Lange, Willem J., Halabi, Carmen M., Modrick, Mary L., Keen, Henry L., Faraci, Frank M., Sigmund, Curt D.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583077/
https://ncbi.nlm.nih.gov/pubmed/18676352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.176339
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