Bioinformatic Analysis of Gene Sets Regulated by Ligand-Activated and Dominant-Negative PPARγ in Mouse Aorta

OBJECTIVE: Drugs that activate PPARγ improve glucose sensitivity and lower blood pressure, whereas dominant negative mutations in PPARγ cause severe insulin resistance and hypertension. We hypothesize that these PPARγ mutants regulate target genes opposite to that of ligand-mediated activation and t...

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Autores principales: Keen, Henry L., Halabi, Carmen M., Beyer, Andreas M., de Lange, Willem J., Liu, Xuebo, Maeda, Nobuyo, Faraci, Frank M., Casavant, Thomas L., Sigmund, Curt D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850258/
https://ncbi.nlm.nih.gov/pubmed/20018933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.200733
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