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Bioinformatic Analysis of Gene Sets Regulated by Ligand-Activated and Dominant-Negative PPARγ in Mouse Aorta
OBJECTIVE: Drugs that activate PPARγ improve glucose sensitivity and lower blood pressure, whereas dominant negative mutations in PPARγ cause severe insulin resistance and hypertension. We hypothesize that these PPARγ mutants regulate target genes opposite to that of ligand-mediated activation and t...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2850258/ https://ncbi.nlm.nih.gov/pubmed/20018933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.200733 |
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