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Hsp27 and F-Box Protein β-TrCP Promote Degradation of mRNA Decay Factor AUF1
Activation of the mitogen-activated protein (MAP) pathway kinases p38 and MK2 induces phosphorylation of the chaperone Hsp27 and stabilization of mRNAs containing AU-rich elements (AREs) (ARE-mRNAs). Likewise, expression of phosphomimetic mutant forms of Hsp27 also stabilizes ARE-mRNAs. It appears t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3648078/ https://ncbi.nlm.nih.gov/pubmed/23530064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00931-12 |
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