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Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCP
Signal-induced phosphorylation of IκBα targets this inhibitor of NF-κB for ubiquitination and subsequent degradation, thus allowing NF-κB to enter the nucleus to turn on its target genes. We report here the identification of an IκB–ubiquitin (Ub) ligase complex containing the F-box/WD40-repeat prote...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC316434/ https://ncbi.nlm.nih.gov/pubmed/9990853 |
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