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Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer
The maintenance and preservation of distinct phases during the cell cycle is a highly complex and coordinated process. It is regulated by phosphorylation — through the activity of cyclin-dependent kinases (CDKs) — and protein degradation, which occurs through ubiquitin ligases such as SCF (SKP1–CUL1...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711846/ https://ncbi.nlm.nih.gov/pubmed/18500245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2396 |
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