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The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number

Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated. E3 ubiquitin ligases have been implicated in controlling the levels of several duplication factors, including...

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Detalhes bibliográficos
Main Authors: Christian Arquint, Fabien Cubizolles, Agathe Morand, Alexander Schmidt, Erich A. Nigg
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2018-02-01
Colecção:Open Biology
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Acesso em linha:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170253
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