The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance)

Docetaxel-related neutropenia was associated with polymorphisms in the drug transporters ABCC2 and SLCO1B3 in Japanese cancer patients. We hypothesized that this association is because of reduced docetaxel clearance, associated with polymorphisms in those genes. We studied 64 US cancer patients who...

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Detalhes bibliográficos
Main Authors: Lewis, Lionel D., Miller, Antonius A., Owzar, Kouros, Bies, Robert R., Markova, Svetlana, Jiang, Chen, Kroetz, Deanna L., Egorin, Merrill J., McLeod, Howard L., Ratain, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647228/
https://ncbi.nlm.nih.gov/pubmed/23188068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32835b16d8
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