Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism That Increases Risk of Docetaxel-Induced Neuropathy

PURPOSE: Discovery of single nucleotide polymorphisms (SNPs) that predict a patient's risk of docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives of this analysis were to discover SNPs associated with docetaxe...

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Pubblicato in:Clin Cancer Res
Autori principali: Hertz, Daniel L., Owzar, Kouros, Lessans, Sherrie, Wing, Claudia, Jiang, Chen, Kelly, William Kevin, Patel, Jai, Halabi, Susan, Furukawa, Yoichi, Wheeler, Heather E., Sibley, Alexander B., Lassiter, Cameron, Weisman, Lois, Watson, Dorothy, Krens, Stefanie D., Mulkey, Flora, Renn, Cynthia L., Small, Eric J., Febbo, Phillip G., Shterev, Ivo, Kroetz, Deanna L., Friedman, Paula N., Mahoney, John F., Carducci, Michael A., Kelley, Michael J, Nakamura, Yusuke, Kubo, Michiaki, Dorsey, Susan G., Dolan, M. Eileen, Morris, Michael J., Ratain, Mark J., McLeod, Howard L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050068/
https://ncbi.nlm.nih.gov/pubmed/27143689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2823
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