Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism That Increases Risk of Docetaxel-Induced Neuropathy

PURPOSE: Discovery of single nucleotide polymorphisms (SNPs) that predict a patient's risk of docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives of this analysis were to discover SNPs associated with docetaxe...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Hertz, Daniel L., Owzar, Kouros, Lessans, Sherrie, Wing, Claudia, Jiang, Chen, Kelly, William Kevin, Patel, Jai, Halabi, Susan, Furukawa, Yoichi, Wheeler, Heather E., Sibley, Alexander B., Lassiter, Cameron, Weisman, Lois, Watson, Dorothy, Krens, Stefanie D., Mulkey, Flora, Renn, Cynthia L., Small, Eric J., Febbo, Phillip G., Shterev, Ivo, Kroetz, Deanna L., Friedman, Paula N., Mahoney, John F., Carducci, Michael A., Kelley, Michael J, Nakamura, Yusuke, Kubo, Michiaki, Dorsey, Susan G., Dolan, M. Eileen, Morris, Michael J., Ratain, Mark J., McLeod, Howard L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050068/
https://ncbi.nlm.nih.gov/pubmed/27143689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2823
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