Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism That Increases Risk of Docetaxel-Induced Neuropathy

PURPOSE: Discovery of single nucleotide polymorphisms (SNPs) that predict a patient's risk of docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives of this analysis were to discover SNPs associated with docetaxe...

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Publicado no:Clin Cancer Res
Main Authors: Hertz, Daniel L., Owzar, Kouros, Lessans, Sherrie, Wing, Claudia, Jiang, Chen, Kelly, William Kevin, Patel, Jai, Halabi, Susan, Furukawa, Yoichi, Wheeler, Heather E., Sibley, Alexander B., Lassiter, Cameron, Weisman, Lois, Watson, Dorothy, Krens, Stefanie D., Mulkey, Flora, Renn, Cynthia L., Small, Eric J., Febbo, Phillip G., Shterev, Ivo, Kroetz, Deanna L., Friedman, Paula N., Mahoney, John F., Carducci, Michael A., Kelley, Michael J, Nakamura, Yusuke, Kubo, Michiaki, Dorsey, Susan G., Dolan, M. Eileen, Morris, Michael J., Ratain, Mark J., McLeod, Howard L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050068/
https://ncbi.nlm.nih.gov/pubmed/27143689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2823
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