Domain-Domain Interactions in Filamin A (16–23) Impose a Hierarchy of Unfolding Forces

The quaternary structure of Filamin A (FLNa) 16–23 was recently shown to exhibit multiple domain-domain interactions that lead to a propeller-like construction. Here we present single-molecule force spectroscopy experiments to show a wide variety of mechanical responses of this molecule and compare...

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Bibliografiske detaljer
Main Authors: Xu, Tianyou, Lannon, Herbert, Wolf, Sébastein, Nakamura, Fumihiko, Brujic, Jasna
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2013
Fag:
Proteins and Nucleic Acids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647155/
https://ncbi.nlm.nih.gov/pubmed/23663845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.03.034
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