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Speed-stability paradox in DNA-scanning by zinc-finger proteins
Extensive contact with DNA via multiple zinc fingers allows highly specific DNA-binding of zinc-finger-class transcription factors, but can also slow the target search process. Here we introduce recent insights into how zinc-finger proteins can rapidly scan DNA. Potential application of the new know...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3646054/ https://ncbi.nlm.nih.gov/pubmed/23412360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.23584 |
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