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Thermodynamic additivity for impacts of base-pair substitutions on association of the Egr-1 zinc-finger protein with DNA
The transcription factor Egr-1 specifically binds as a monomer to its 9-bp target DNA sequence, GCGTGGGCG, via three zinc fingers and plays important roles in the brain and cardiovascular systems. Using fluorescence-based competitive binding assays, we systematically analyzed the impacts of all poss...
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| Опубликовано в: : | Biochemistry |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5175577/ https://ncbi.nlm.nih.gov/pubmed/27933778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00757 |
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