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Thermodynamic additivity for impacts of base-pair substitutions on association of the Egr-1 zinc-finger protein with DNA
The transcription factor Egr-1 specifically binds as a monomer to its 9-bp target DNA sequence, GCGTGGGCG, via three zinc fingers and plays important roles in the brain and cardiovascular systems. Using fluorescence-based competitive binding assays, we systematically analyzed the impacts of all poss...
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| Vydáno v: | Biochemistry |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5175577/ https://ncbi.nlm.nih.gov/pubmed/27933778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00757 |
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