Delivery of interferon alpha using a novel Cox2-controlled adenovirus for pancreatic cancer therapy

BACKGROUND: Combination therapy with interferon alpha (IFN) is correlated with improved survival in patients with pancreatic ductal adenocarcinoma (PDAc) but frequently presents side effects. We designed a novel targeted adenovirus with replication restricted to cyclooxygenase 2 (Cox2)-overexpressin...

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Autors principals: Armstrong, Leonard, Davydova, Julia, Brown, Eric, Han, Joohee, Yamamoto, Masato, Vickers, Selwyn M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645277/
https://ncbi.nlm.nih.gov/pubmed/22503318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2012.02.017
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