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Oncolytic adenovirus expressing interferon alpha in a syngeneic Syrian hamster model for the treatment of pancreatic cancer

BACKGROUND: The addition of interferon alpha (IFN) to adjuvant chemoradiotherapy regimens resulted in remarkable improvements in survival for pancreatic cancer patients. However, systemic toxicities and insufficient levels of IFN at the tumor sites have limited its widespread adoption in treatment s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Surgery
Hauptverfasser: LaRocca, Christopher J., Han, Joohee, Gavrikova, Tatyana, Armstrong, Leonard, Oliveira, Amanda R., Shanley, Ryan, Vickers, Selwyn M., Yamamoto, Masato, Davydova, Julia
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417428/
https://ncbi.nlm.nih.gov/pubmed/25731784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2015.01.006
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