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Combination of interferon-expressing oncolytic adenovirus with chemotherapy and radiation is highly synergistic in hamster model of pancreatic cancer

Recent clinical trials utilizing Interferon-alpha (IFN) in combination with chemoradiation have demonstrated significant improvements in the survival of patients with pancreatic cancer. However, efficacy was limited by the systemic toxicity of IFN and low intratumoral levels of the cytokine. We soug...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Salzwedel, Amanda O., Han, Joohee, LaRocca, Christopher J., Shanley, Ryan, Yamamoto, Masato, Davydova, Julia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915056/
https://ncbi.nlm.nih.gov/pubmed/29719589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24710
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