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Variable contributions of basic residues forming an APC exosite in the binding and inactivation of factor VIIIa()
Basic residues contained in the 39-, 60-, and 70–80-loops of activated protein C (APC) comprise an exosite that contributes to the binding and subsequent proteolytic inactivation of factor (F) VIIIa. Surface plasmon resonance (SPR) showed that WT APC bound to FVIII light chain (LC) and the FVIIIa A1...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3645000/ https://ncbi.nlm.nih.gov/pubmed/23480827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301632g |
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