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Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment
In an evolutionarily conserved signaling pathway, ‘soluble’ adenylyl cyclases (sACs) synthesize the ubiquitous second messenger cyclic adenosine 3′,5′-monophosphate (cAMP) in response to bicarbonate and calcium signals. Here, we present crystal structures of a cyanobacterial sAC enzyme in complex wi...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3644947/ https://ncbi.nlm.nih.gov/pubmed/15619637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb880 |
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