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Comparative analysis using K-mer and K-flank patterns provides evidence for CpG island sequence evolution in mammalian genomes

CpG islands are GC-rich regions often located in the 5′ end of genes and normally protected from cytosine methylation in mammals. The important role of CpG islands in gene transcription strongly suggests evolutionary conservation in the mammalian genome. However, as CpG dinucleotides are over-repres...

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Bibliografski detalji
Glavni autori: Chae, Heejoon, Park, Jinwoo, Lee, Seong-Whan, Nephew, Kenneth P., Kim, Sun
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643570/
https://ncbi.nlm.nih.gov/pubmed/23519616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt144
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