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Comparative analysis using K-mer and K-flank patterns provides evidence for CpG island sequence evolution in mammalian genomes

CpG islands are GC-rich regions often located in the 5′ end of genes and normally protected from cytosine methylation in mammals. The important role of CpG islands in gene transcription strongly suggests evolutionary conservation in the mammalian genome. However, as CpG dinucleotides are over-repres...

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Autori principali: Chae, Heejoon, Park, Jinwoo, Lee, Seong-Whan, Nephew, Kenneth P., Kim, Sun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643570/
https://ncbi.nlm.nih.gov/pubmed/23519616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt144
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