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CFTR: folding, misfolding and correcting the ΔF508 conformational defect
Cystic fibrosis (CF), the most common lethal genetic disease in the Caucasian population, is caused by loss-of-function mutations of the CF transmembrane conductance regulator (CFTR), a cyclic AMP-regulated plasma membrane chloride channel. The most common mutation, deletion of phenylalanine 508 (ΔF...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3643519/ https://ncbi.nlm.nih.gov/pubmed/22138491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2011.10.003 |
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