The Human Tim-Tipin Complex Interacts Directly with DNA Polymerase ϵ and Stimulates Its Synthetic Activity

The Tim-Tipin complex plays an important role in the S phase checkpoint and replication fork stability in metazoans, but the molecular mechanism underlying its biological function is poorly understood. Here, we present evidence that the recombinant human Tim-Tipin complex (and Tim alone) markedly en...

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Main Authors: Aria, Valentina, De Felice, Mariarita, Di Perna, Roberta, Uno, Shuji, Masai, Hisao, Syväoja, Juhani E., van Loon, Barbara, Hübscher, Ulrich, Pisani, Francesca M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
DNA and Chromosomes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642320/
https://ncbi.nlm.nih.gov/pubmed/23511638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.398073
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