Segregation of Replicative DNA Polymerases during S Phase: DNA POLYMERASE ϵ, BUT NOT DNA POLYMERASES α/δ, ARE ASSOCIATED WITH LAMINS THROUGHOUT S PHASE IN HUMAN CELLS

DNA polymerases (Pol) α, δ, and ϵ replicate the bulk of chromosomal DNA in eukaryotic cells, Pol ϵ being the main leading strand and Pol δ the lagging strand DNA polymerase. By applying chromatin immunoprecipitation (ChIP) and quantitative PCR we found that at G(1)/S arrest, all three DNA polymerase...

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Main Authors: Vaara, Markku, Itkonen, Harri, Hillukkala, Tomi, Liu, Zhe, Nasheuer, Heinz-Peter, Schaarschmidt, Daniel, Pospiech, Helmut, Syväoja, Juhani E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460436/
https://ncbi.nlm.nih.gov/pubmed/22887995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.357996
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