In Vitro Gap-directed Translesion DNA Synthesis of an Abasic Site Involving Human DNA Polymerases ϵ, λ, and β

DNA polymerase (pol) ϵ is thought to be the leading strand replicase in eukaryotes, whereas pols λ and β are believed to be mainly involved in re-synthesis steps of DNA repair. DNA elongation by the human pol ϵ is halted by an abasic site (apurinic/apyrimidinic (AP) site). In this study, we present...

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Hauptverfasser: Villani, Giuseppe, Hubscher, Ulrich, Gironis, Nadege, Parkkinen, Sinikka, Pospiech, Helmut, Shevelev, Igor, di Cicco, Giulia, Markkanen, Enni, Syväoja, Juhani E., Tanguy Le Gac, Nicolas
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173188/
https://ncbi.nlm.nih.gov/pubmed/21757740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.246611
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