A switch between DNA polymerases δ and λ promotes error-free bypass of 8-oxo-G lesions

7,8-Dihydro-8-oxoguanine (8-oxo-G) is a highly abundant and mutagenic lesion. Replicative DNA polymerases (pols) are slowed down at 8-oxo-G and insert both correct cytosine (C) and incorrect adenine (A) opposite 8-oxo-G, but they preferentially extend A:8-oxo-G mispairs. Nevertheless, 8-oxo-G bypass...

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Bibliografische gegevens
Hoofdauteurs: Markkanen, Enni, Castrec, Benoît, Villani, Giuseppe, Hübscher, Ulrich
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2012
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528542/
https://ncbi.nlm.nih.gov/pubmed/23175785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211532109
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