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A switch between DNA polymerases δ and λ promotes error-free bypass of 8-oxo-G lesions
7,8-Dihydro-8-oxoguanine (8-oxo-G) is a highly abundant and mutagenic lesion. Replicative DNA polymerases (pols) are slowed down at 8-oxo-G and insert both correct cytosine (C) and incorrect adenine (A) opposite 8-oxo-G, but they preferentially extend A:8-oxo-G mispairs. Nevertheless, 8-oxo-G bypass...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3528542/ https://ncbi.nlm.nih.gov/pubmed/23175785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211532109 |
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