Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion

7,8-dihydro-8-oxoguanine (oxoG), the predominant lesion formed following oxidative damage of DNA by reactive oxygen species, is processed differently by replicative and bypass polymerases. Our kinetic primer extension studies demonstrate that the bypass polymerase Dpo4 preferentially inserts C oppos...

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Detalhes bibliográficos
Main Authors: Rechkoblit, Olga, Malinina, Lucy, Cheng, Yuan, Kuryavyi, Vitaly, Broyde, Suse, Geacintov, Nicholas E, Patel, Dinshaw J
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1325099/
https://ncbi.nlm.nih.gov/pubmed/16379496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040011
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