Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion

7,8-dihydro-8-oxoguanine (oxoG), the predominant lesion formed following oxidative damage of DNA by reactive oxygen species, is processed differently by replicative and bypass polymerases. Our kinetic primer extension studies demonstrate that the bypass polymerase Dpo4 preferentially inserts C oppos...

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Bibliographic Details
Main Authors: Rechkoblit, Olga, Malinina, Lucy, Cheng, Yuan, Kuryavyi, Vitaly, Broyde, Suse, Geacintov, Nicholas E, Patel, Dinshaw J
Format: Artigo
Language:Inglês
Published: Public Library of Science 2006
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1325099/
https://ncbi.nlm.nih.gov/pubmed/16379496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040011
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