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Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
7,8-dihydro-8-oxoguanine (oxoG), the predominant lesion formed following oxidative damage of DNA by reactive oxygen species, is processed differently by replicative and bypass polymerases. Our kinetic primer extension studies demonstrate that the bypass polymerase Dpo4 preferentially inserts C oppos...
Gorde:
| Egile Nagusiak: | , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Public Library of Science
2006
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1325099/ https://ncbi.nlm.nih.gov/pubmed/16379496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040011 |
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