Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants.

Overexpression and autocrine activation of the epidermal growth factor receptor (EGF-R) cause transformation of cultured cells and correlate with tumor progression in cancer patients. Dimerization and transphosphorylation are crucial events in the process by which receptors with tyrosine kinase acti...

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Main Authors: Redemann, N, Holzmann, B, von Rüden, T, Wagner, E F, Schlessinger, J, Ullrich, A
Format: Artigo
Jezik:Inglês
Izdano: 1992
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC364201/
https://ncbi.nlm.nih.gov/pubmed/1346334
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