CpG-ODN Attenuates Pathological Cardiac Hypertrophy and Heart Failure by Activation of PI3Kα-Akt Signaling

Phosphoinositide-3-kinase α (PI3Kα) represents a potential novel drug target for pathological cardiac hypertrophy (PCH) and heart failure. Oligodeoxynucleotides containing CpG motifs (CpG-ODN) are classic agonists of Toll-like receptor 9 (TLR9), which typically activates PI3K-Akt signaling in immune...

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Autores principales: Yang, Liang, Cai, Xiangyu, Liu, Jie, Jia, Zhe, Jiao, Jinjin, Zhang, Jincai, Li, Changlin, Li, Jing, Tang, Xiang D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640052/
https://ncbi.nlm.nih.gov/pubmed/23638055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062373
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