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MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7
Suppression of extracellular signal-regulated kinase (ERK) signaling is an absolute requirement for the maintenance of murine pluripotent stem cells (mPSCs) and requires the MYC-binding partner MAX. In this study, we define a mechanism for this by showing that MYC/MAX complexes suppress ERK activity...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cold Spring Harbor Laboratory Press
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3639414/ https://ncbi.nlm.nih.gov/pubmed/23592794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.211300.112 |
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