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MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7

Suppression of extracellular signal-regulated kinase (ERK) signaling is an absolute requirement for the maintenance of murine pluripotent stem cells (mPSCs) and requires the MYC-binding partner MAX. In this study, we define a mechanism for this by showing that MYC/MAX complexes suppress ERK activity...

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Bibliografske podrobnosti
Main Authors: Chappell, James, Sun, Yuhua, Singh, Amar, Dalton, Stephen
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639414/
https://ncbi.nlm.nih.gov/pubmed/23592794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.211300.112
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