DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

Human DNA polymerase η (Pol η) is best known for its role in responding to UV irradiation–induced genome damage. We have recently observed that Pol η is also required for the stability of common fragile sites (CFSs), whose rearrangements are considered a driving force of oncogenesis. Here, we explor...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Bergoglio, Valérie, Boyer, Anne-Sophie, Walsh, Erin, Naim, Valeria, Legube, Gaëlle, Lee, Marietta Y.W.T., Rey, Laurie, Rosselli, Filippo, Cazaux, Christophe, Eckert, Kristin A., Hoffmann, Jean-Sébastien
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2013
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639397/
https://ncbi.nlm.nih.gov/pubmed/23609533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201207066
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki