DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

Human DNA polymerase η (Pol η) is best known for its role in responding to UV irradiation–induced genome damage. We have recently observed that Pol η is also required for the stability of common fragile sites (CFSs), whose rearrangements are considered a driving force of oncogenesis. Here, we explor...

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Detalhes bibliográficos
Main Authors: Bergoglio, Valérie, Boyer, Anne-Sophie, Walsh, Erin, Naim, Valeria, Legube, Gaëlle, Lee, Marietta Y.W.T., Rey, Laurie, Rosselli, Filippo, Cazaux, Christophe, Eckert, Kristin A., Hoffmann, Jean-Sébastien
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639397/
https://ncbi.nlm.nih.gov/pubmed/23609533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201207066
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