Simultaneous Disruption of Two DNA Polymerases, Polη and Polζ, in Avian DT40 Cells Unmasks the Role of Polη in Cellular Response to Various DNA Lesions

Replicative DNA polymerases are frequently stalled by DNA lesions. The resulting replication blockage is released by homologous recombination (HR) and translesion DNA synthesis (TLS). TLS employs specialized TLS polymerases to bypass DNA lesions. We provide striking in vivo evidence of the cooperati...

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Hlavní autoři: Hirota, Kouji, Sonoda, Eiichiro, Kawamoto, Takuo, Motegi, Akira, Masutani, Chikahide, Hanaoka, Fumio, Szüts, Dávid, Iwai, Shigenori, Sale, Julian E., Lehmann, Alan, Takeda, Shunichi
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951353/
https://ncbi.nlm.nih.gov/pubmed/20949111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001151
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