Simultaneous Disruption of Two DNA Polymerases, Polη and Polζ, in Avian DT40 Cells Unmasks the Role of Polη in Cellular Response to Various DNA Lesions

Replicative DNA polymerases are frequently stalled by DNA lesions. The resulting replication blockage is released by homologous recombination (HR) and translesion DNA synthesis (TLS). TLS employs specialized TLS polymerases to bypass DNA lesions. We provide striking in vivo evidence of the cooperati...

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Bibliografski detalji
Glavni autori: Hirota, Kouji, Sonoda, Eiichiro, Kawamoto, Takuo, Motegi, Akira, Masutani, Chikahide, Hanaoka, Fumio, Szüts, Dávid, Iwai, Shigenori, Sale, Julian E., Lehmann, Alan, Takeda, Shunichi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951353/
https://ncbi.nlm.nih.gov/pubmed/20949111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001151
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