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Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
We show that comprehensive sequence-function maps obtained by deep sequencing can be used to reprogram interaction specificity and to leapfrog over bottlenecks in affinity maturation by combining many individually small contributions not detectable in conventional approaches. We use this approach to...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3638900/ https://ncbi.nlm.nih.gov/pubmed/22634563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2214 |
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