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Computational design of proteins targeting the conserved stem region of influenza hemagglutinin

We describe a general computational method for designing proteins that bind a surface patch of interest on a target macromolecule. Favorable interactions between disembodied amino-acid residues and the target surface are identified and used to anchor de novo designed interfaces. The method was used...

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Detalhes bibliográficos
Main Authors: Fleishman, Sarel J, Whitehead, Timothy A, Ekiert, Damian C, Dreyfus, Cyrille, Corn, Jacob E, Strauch, Eva-Maria, Wilson, Ian A, Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164876/
https://ncbi.nlm.nih.gov/pubmed/21566186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1202617
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