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Computational design of proteins targeting the conserved stem region of influenza hemagglutinin
We describe a general computational method for designing proteins that bind a surface patch of interest on a target macromolecule. Favorable interactions between disembodied amino-acid residues and the target surface are identified and used to anchor de novo designed interfaces. The method was used...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164876/ https://ncbi.nlm.nih.gov/pubmed/21566186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1202617 |
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