Metronomic Activity of CD44-Targeted Hyaluronic Acid-Paclitaxel in Ovarian Carcinoma

PURPOSE: Most primary human ovarian tumors and peritoneal implants, as well as tumor vascular endothelial cells, express the CD44 family of cell surface proteoglycans, the natural ligand for which is hyaluronic acid (HA). Metronomic (MET) dosing, the frequent administration of chemotherapeutics at s...

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Detalhes bibliográficos
Main Authors: Lee, Sun Joo, Ghosh, Sukhen C., Han, Hee Dong, Stone, Rebecca L., Bottsford-Miller, Justin, Shen, De Yue, Auzenne, Edmond J., Lopez-Araujo, Alejandro, Lu, Chunhua, Nishimura, Masato, Pecot, Chad V., Zand, Behrouz, Thanapprapasr, Duangmani, Jennings, Nicholas B, Kang, Yu, Huang, Jie, Hu, Wei, Klostergaard, Jim, Sood, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638880/
https://ncbi.nlm.nih.gov/pubmed/22693353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-3250
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