Metronomic Activity of CD44-Targeted Hyaluronic Acid-Paclitaxel in Ovarian Carcinoma

PURPOSE: Most primary human ovarian tumors and peritoneal implants, as well as tumor vascular endothelial cells, express the CD44 family of cell surface proteoglycans, the natural ligand for which is hyaluronic acid (HA). Metronomic (MET) dosing, the frequent administration of chemotherapeutics at s...

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Autori principali: Lee, Sun Joo, Ghosh, Sukhen C., Han, Hee Dong, Stone, Rebecca L., Bottsford-Miller, Justin, Shen, De Yue, Auzenne, Edmond J., Lopez-Araujo, Alejandro, Lu, Chunhua, Nishimura, Masato, Pecot, Chad V., Zand, Behrouz, Thanapprapasr, Duangmani, Jennings, Nicholas B, Kang, Yu, Huang, Jie, Hu, Wei, Klostergaard, Jim, Sood, Anil K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638880/
https://ncbi.nlm.nih.gov/pubmed/22693353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-3250
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