Hyaluronic Acid-Paclitaxel: Antitumor Efficacy against CD44(+) Human Ovarian Carcinoma Xenografts

Numerous human tumor types, including ovarian cancer, display a significant expression of the CD44 family of cell surface proteoglycans. To develop tumor-targeted drugs, we have initially evaluated whether the CD44 ligand hyaluronic acid (HA) could serve as a backbone for paclitaxel (TXL) prodrugs....

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Autores principales: Auzenne, Edmond, Ghosh, Sukhen C, Khodadadian, Mojgan, Rivera, Belinda, Farquhar, David, Price, Roger E, Ravoori, Murali, Kundra, Vikas, Freedman, Ralph S, Klostergaard, Jim
Formato: Artigo
Lenguaje:Inglês
Publicado: Neoplasia Press Inc. 2007
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899257/
https://ncbi.nlm.nih.gov/pubmed/17603630
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