Acid Ceramidase Maintains the Chondrogenic Phenotype of Expanded Primary Chondrocytes and Improves the Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells

Acid ceramidase is required to maintain the metabolic balance of several important bioactive lipids, including ceramide, sphingosine and sphingosine-1-phosphate. Here we show that addition of recombinant acid ceramidase (rAC) to primary chondrocyte culture media maintained low levels of ceramide and...

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Hauptverfasser: Simonaro, Calogera M., Sachot, Sylvain, Ge, Yi, He, Xingxuan, DeAngelis, Victor A., Eliyahu, Efrat, Leong, Daniel J., Sun, Hui B., Mason, Jeffrey B., Haskins, Mark E., Richardson, Dean W., Schuchman, Edward H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637164/
https://ncbi.nlm.nih.gov/pubmed/23638138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062715
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