PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells

Protein kinase R (PKR) is an interferon (IFN)-inducible, double-stranded RNA-activated kinase that initiates apoptosis in response to cellular stress. To determine the role of PKR in hematopoiesis, we developed transgenic mouse models that express either human PKR (TgPKR) or a dominant-negative PKR...

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Hlavní autoři: Liu, Xiangfei, Bennett, Richard L., Cheng, Xiaodong, Byrne, Michael, Reinhard, Mary K., May, W. Stratford
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637012/
https://ncbi.nlm.nih.gov/pubmed/23403623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-456400
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