Detrimental Effects of Diet-Induced Obesity on τ Pathology Are Independent of Insulin Resistance in τ Transgenic Mice

The τ pathology found in Alzheimer disease (AD) is crucial in cognitive decline. Midlife development of obesity, a major risk factor of insulin resistance and type 2 diabetes, increases the risk of dementia and AD later in life. The impact of obesity on AD risk has been suggested to be related to ce...

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Autors principals: Leboucher, Antoine, Laurent, Cyril, Fernandez-Gomez, Francisco-José, Burnouf, Sylvie, Troquier, Laetitia, Eddarkaoui, Sabiha, Demeyer, Dominique, Caillierez, Raphaëlle, Zommer, Nadège, Vallez, Emmanuelle, Bantubungi, Kadiombo, Breton, Christophe, Pigny, Pascal, Buée-Scherrer, Valérie, Staels, Bart, Hamdane, Malika, Tailleux, Anne, Buée, Luc, Blum, David
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2013
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636620/
https://ncbi.nlm.nih.gov/pubmed/23250356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0866
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