Tau deletion promotes brain insulin resistance

The molecular pathways underlying tau pathology–induced synaptic/cognitive deficits and neurodegeneration are poorly understood. One prevalent hypothesis is that hyperphosphorylation, misfolding, and fibrillization of tau impair synaptic plasticity and cause degeneration. However, tau pathology may...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Marciniak, Elodie, Leboucher, Antoine, Caron, Emilie, Ahmed, Tariq, Tailleux, Anne, Dumont, Julie, Issad, Tarik, Gerhardt, Ellen, Pagesy, Patrick, Vileno, Margaux, Bournonville, Clément, Hamdane, Malika, Bantubungi, Kadiombo, Lancel, Steve, Demeyer, Dominique, Eddarkaoui, Sabiha, Vallez, Emmanuelle, Vieau, Didier, Humez, Sandrine, Faivre, Emilie, Grenier-Boley, Benjamin, Outeiro, Tiago F., Staels, Bart, Amouyel, Philippe, Balschun, Detlef, Buee, Luc, Blum, David
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551570/
https://ncbi.nlm.nih.gov/pubmed/28652303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161731
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