A pharmacogenetic study of vorinostat glucuronidation

High interindividual pharmacokinetic variability was observed in phase 1 studies of vorinostat (suberoylanilide hydroxamic acid), an oral histone deacetylase inhibitor. Thus, we hypothesized that the variability can be explained by genetic variants of the uridine 5′-diphosphate-glucuronosyltransfera...

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Bibliografiske detaljer
Main Authors: Kang, Soonmo Peter, Ramirez, Jacqueline, House, Larry, Zhang, Wei, Mirkov, Snezana, Liu, Wanqing, Haverfield, Eden, Ratain, Mark J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636562/
https://ncbi.nlm.nih.gov/pubmed/20729791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32833e1b37
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