A PHARMACOGENETIC STUDY OF ALDEHYDE OXIDASE I IN PATIENTS TREATED WITH XK469

XK469 (NSC 697887) is a selective topoisomerase II β inhibitor eliminated mainly via aldehyde oxidase I (AOX1). We performed a candidate gene study to investigate whether AOX1 genetic variation contributes to interindividual variability in XK469 clearance. Forty-one AOX1 single nucleotide polymorphi...

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Hoofdauteurs: Ramírez, Jacqueline, Kim, Tae Won, Liu, Wanqing, Myers, Jamie L., Mirkov, Snezana, Owzar, Kouros, Watson, Dorothy, Mulkey, Flora, Gamazon, Eric R., Stock, Wendy, Undevia, Samir, Innocenti, Federico, Ratain, Mark J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901533/
https://ncbi.nlm.nih.gov/pubmed/24300566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000023
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