A phase I and pharmacokinetic study of the quinoxaline antitumour Agent R(+)XK469 in patients with advanced solid tumours

PURPOSE: To investigate the safety and pharmacokinetics of R(+)XK469, a quinoxaline analogue, in patients with advanced refractory solid tumours. Preclinical studies suggested that efficacy was independent of schedule but that toxicity was decreased by dividing the dose. METHODS: R(+)XK469 was initi...

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Hlavní autoři: Undevia, Samir D., Innocenti, Federico, Ramirez, Jacqueline, House, Larry, Desai, Apurva A., Skoog, Linda A., Singh, Deepti A., Karrison, Theodore, Kindler, Hedy L., Ratain, Mark J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731567/
https://ncbi.nlm.nih.gov/pubmed/18650079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2008.05.018
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