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Inhibition of paracetamol glucuronidation by tyrosine kinase inhibitors

AIMS: We aimed to investigate the effects of tyrosine kinase inhibitors (TKIs) on paracetamol (acetaminophen) glucuronidation. METHODS: The inhibition of nine small molecule TKIs on paracetamol glucuronidation was investigated in human liver microsomes (HLMs) and recombinant human UDP-glucuronosyltr...

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Detalhes bibliográficos
Main Authors: Liu, Yong, Ramírez, Jacqueline, Ratain, Mark J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099378/
https://ncbi.nlm.nih.gov/pubmed/21235620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03911.x
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