In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole

AIMS: Little information is available regarding the metabolic routes of anastrozole and the specific enzymes involved. We characterized anastrozole oxidative and conjugation metabolism in vitro and in vivo. METHODS: A sensitive LC-MS/MS method was developed to measure anastrozole and its metabolites...

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Autores principales: Kamdem, Landry K, Liu, Yong, Stearns, Vered, Kadlubar, Susan A, Ramirez, Jacqueline, Jeter, Stacie, Shahverdi, Karineh, Ward, Bryan A, Ogburn, Evan, Ratain, Mark J, Flockhart, David A, Desta, Zeruesenay
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2010
Materias:
Drug Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014069/
https://ncbi.nlm.nih.gov/pubmed/21175441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03791.x
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